Allergists, paediatricians, allergy foundations and doctors alike recommend regular cleaning of beds. The American Academy of Allergy and Clinical Immunology (AAAI) advises vacuuming your beds every two to three months. Good Housekeeping magazine recommends vacuuming your mattress every three weeks, while other sources recommend vacuuming on a monthly basis. At the very least, make the mattress vacuum a part of your seasonal cleaning.
In hospitality, every time guests check out you should sanitise the bed, the same way you change the sheets.